Author's response to reviews Title: 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents Authors:
نویسندگان
چکیده
Timo D Muller ([email protected]) Anke Hinney ([email protected]) Andre Scherag ([email protected]) Thuy T Nguyen ([email protected]) Felix Schreiner ([email protected]) Helmut Schaefer ([email protected]) Johannes Hebebrand ([email protected]) Christian L Roth ([email protected]) Thomas Reinehr ([email protected])
منابع مشابه
Association of Obesity Related Genetic Variants (FTO and MC4R) with Breast Cancer Risk:a population-based case-control study in Iran
Background: The heterogeneous breast cancer is the most common cause of cancer-related mortality. Obesity defined by BMI is known as a major risk factor for breast cancer. Objective: The purpose of this study was to explore the role of obesity related-polymorphisms rs9939609 FTO and rs17782313 MC4R in breast cancer development. Materials and Methods: We obtained matched peripheral blood, serum ...
متن کاملEffects of the FTO gene on lifestyle intervention studies in children.
The effects of FTO on body weight, body composition, and the risk of developing overweight and obesity in children, adolescents, and adults are analyzed in this review. Most trails have been conducted on the rs9939609 SNP of the FTO gene. The minor A-allele frequency ranged from 0.38 to 0.49 in different European populations. Briefly, it has been reported that overweight-obesity risk per A-alle...
متن کاملFTO rs 9939609 SNP Is Associated With Adiponectin and Leptin Levels and the Risk of Obesity in a Cohort of Romanian Children Population
Obesity is a disorder with increasing frequency in children and adolescents, directly linked with various diseases. Variants in the FTO (fat mass and obesity-related) gene have been associated with body mass index and waist and hip circumferences in widespread populations.The aim of this case-control study was to assess if there is any association between FTO gene variants rs9939609, respective...
متن کاملRs9939609 Variant of the Fat Mass and Obesity-Associated Gene and Trunk Obesity in Adolescents
A common T/A polymorphism (rs9939609) in the fat mass and obesity associated (FTO) gene was found associated with early-onset and severe obesity in both adults and children. However, recent observations failed to find associations of FTO with obesity. To investigate the genetic background of early obesity, we analysed the single nucleotide polymorphism (SNP) rs9939609 of FTO in 371 styrian adol...
متن کاملCommon variants in genes related to lipid and energy metabolism are associated with weight loss after an intervention in overweight/obese adolescents.
BACKGROUND Some SNPs related to lipid and energy metabolism may be implicated not only in the development of obesity and associated comorbidities, but also in the weight loss response after a nutritional intervention. OBJECTIVE In this context, the present study analyzed four SNPs located within four genes known to be associated with obesity and other obesity-related complications, and their ...
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تاریخ انتشار 2008